The efficacy and prophylactic characteristics of omega-3 fatty acids in experimental gingivitis in rats

نویسندگان

  • Bagher Minaii Department of Histology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Abdollahi Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mojgan Alaeddini Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mojgan Paknejad Department of Periodontology, Tehran University of Medical Sciences, Tehran, Iran
  • Nasrin Araghizadeh Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Reza Khorasanie Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

Objective(s):Gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. The aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. Materials and Methods: Gingival inflammation was induced by lipopolysaccharide (LPS) injection. Forty adult male rats were divided into four equal groups: 1. Negative control group (sterile saline was injected into gingival tissue followed by oral gavage with saline); 2. Positive control group (LPS injection was followed by oral gavage with saline); 3. Treatment group (LPS injection was followed by oral gavage with omega-3); 4. Prophylactic group (oral gavage with omega-3 was followed by LPS injection). After 24 days, the rats were sacrificed and histological tissue samples were randomly evaluated for the inflammatory tissue changes. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels were measured by ELISA. Results: The levels of IL-1β and TNF-α in the prophylactic group and the level of TNF-α in the treatment group were significantly lower than those in the positive control group (P

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the efficacy and prophylactic characteristics of omega-3 fatty acids in experimental gingivitis in rats

objective(s):gingivitis is an inflammatory disease that affects tooth-supporting tissues and is caused by a microbe-immune response. the aim of this study was to evaluate the effects of omega-3 fatty acids on immune system regulation and the prevention and treatment of gingivitis using an animal model. materials and methods: gingival inflammation was induced by lipopolysaccharide (lps) injectio...

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عنوان ژورنال

دوره 17  شماره 2

صفحات  87- 92

تاریخ انتشار 2014-02-01

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